Endocrine Abstracts

Aim: To analyze the effects of inositol administration on parameters related to glucose homeostasis.Material and methods: Systematic review and meta-analysis of articles published in Medline or Web of Science Until February 1, 2016. We included studies that met the following criteria: i) Randomized controlled clinical trials of inositol/inositol isomer supplementation against placebo in parallel design, ii) performed in humans, iii) with information abou...

Context: In the background population, maternal TSH levels >2.5 mUI/l in late pregnancy have been reported to be associated with breech presentation. This has not been addressed in women treated with levothyroxine.Aim: Our aim was to study the relationship of 3rd trimester maternal TSH with caesarean section (CS) due to foetal malposition in pregnant women treated with levothyroxine since before pregnancy.Methods: We have studi...

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases. Genetic analysis performed for genetic counselling revealed a miscorrelation with the clinical diagnosis in several patients at our centre.Aim: Confirm the genetic diagnosis of NCCAH in women attended for this condition.Materials and methods: Consecutive patients attended at o...

Introduction: Pregnancy in hypopituitary women is a rare and poorly studied clinical condition. Management difficulties and obstetrical complications have been associated with this condition.Objectives: To define the characteristics, follow-up and perinatal outcomes in hypopituitary pregnant women attended at our centre.Methods: The clinical data of the hypopituitary pregnant women (deficiency of two or more pituitary hormones), an...

Introduction: Several clinical and molecular markers can be used to establish risk at the time of diagnosis in DTC. Thyroglobulin (Tg), which is essential in follow up, could be an early marker to identify risk patients. Around 25% of patients require 18 months or longer to have indetectable Tg. The presence of Tg antibodies (TgAb) invalidate the follow up of DTC via Tg and this is usually associated with a poor prognosis.Aim: To evaluate the role of Tg ...

Introduction: Cushing’s syndrome (CS) is associated with increased mortality and morbidities. Hypercortisolism is also present in chronic mood disorders (CMD) and stress, where telomere length (TL) has been found to be shorter than in matched controls. Since hypercortisolism is present in CS and CMD, we hypothesized that telomere shortening could also be present in CS. The aim of this study was to investigate TL in CS patients compared to matched controls.<p class="ab...